Microfluidic Sperm Sorting

This is a chemical free method of selecting sperms using a disposable chip. It is a new gentle alternative for sperm processing which has been shown to reduce DNA Fragmentation (DFI) in sperms with high DNA fragmentation to nearly undetectable levels.
One of the common cause of high Sperm DNA fragmentation (High DFI) is the generation of Reactive Oxygen Species (ROS) due to oxidative stress. This ROS could be generated during the process of Centrifugation which is involved in Sperm Preparation for use during the IVF/ICSI procedure.
Microfluidic sperm sorting does not require centrifugation and as such limits the possibility of the generation of ROS during sperm preparation for treatment. Some studies have shown that frequent ejaculation, use of antioxidants and TESA could help reduce high DFI. Frequent ejaculation and TESA have recorded some positive results so far. Studies have suggested that High DFI is associated with low fertilization rates, poor embryo quality and development, poor blastulation and decreased pregnancy rates especially for DFI results above 25%.